약학대학 - 약학대학

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    Lab 분자병태생리학

관심분야

Tumor Microenvironment Coordination & Drug Resistance 
Drug Discovery against Ocular Diseases 
Agonistic CAR-T Cell Therapy

학력

  • (Ph.D.) College of Pharmacy, Seoul National University (2009)

약력/경력

  • Postdoctoral Fellow, College of Pharmacy, Seoul National University (2009-2010)
  • Postdoctoral Fellow, University of Texas, M.D. Anderson Cancer Center (2010-2011)
  • Full-time Lecturer, Assistant and Associate Professor, College of Pharmacy, Inje University (2011-2020)
  • Associate Professor, School of Pharmacy, Sungkyunkwan University (2020-present)

학술지 논문

  • (2023)  1,8-Dihydroxy-3-methoxy-anthraquinone inhibits tumor angiogenesis through HIF-1α downregulation.  BIOCHEMICAL PHARMACOLOGY.  220,  1
  • (2023)  Ginsenoside Re inhibits melanogenesis and melanoma growth by downregulating microphthalmia-associated transcription factor.  BIOMEDICINE & PHARMACOTHERAPY.  165, 
  • (2023)  The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling.  EXPERIMENTAL AND MOLECULAR MEDICINE.  55,  6
  • (2023)  Discovery and Biosynthesis of Imidazolium Antibiotics from the Probiotic Bacillus licheniformis.  JOURNAL OF NATURAL PRODUCTS.  86,  4
  • (2022)  miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.  CELL DEATH AND DIFFERENTIATION.  29,  6
  • (2022)  Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/beta-Catenin signaling through Frizzled2-LRP6 assembly.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH.  41,  1
  • (2022)  An aqueous extract from Artemisia capillaris inhibits acute gastric injury through mucosal stabilization.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE.  102,  3
  • (2022)  Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF-kappa B.  BIOMEDICINE & PHARMACOTHERAPY.  145,  -
  • (2021)  Claudin-5a knockdown attenuates blood-neural barrier in zebrafish.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY.  250,  109176
  • (2021)  Enhanced anti-angiogenic activity of novel melatonin-like agents.  JOURNAL OF PINEAL RESEARCH.  71,  1
  • (2021)  Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity.  ANTIOXIDANTS.  10,  5
  • (2021)  Identification of differentially expressed genes in mouse embryonic stem cell under hypoxia.  GENES GENOMICS.  43,  4
  • (2021)  Phaseolin Attenuates Lipopolysaccharide-Induced Inflammation in RAW 264.7 Cells and Zebrafish.  BIOMEDICINES.  9,  4
  • (2021)  RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse.  JOURNAL OF CLINICAL INVESTIGATION.  131,  1
  • (2020)  The ATF6-EGF Pathway Mediates the Awakening of Slow-Cycling Chemoresistant Cells and Tumor Recurrence by Stimulating Tumor Angiogenesis.  CANCERS.  12,  7
  • (2020)  The Interplay between Slow-Cycling, Chemoresistant Cancer Cells and Fibroblasts Creates a Proinflammatory Niche for Tumor Progression.  CANCER RESEARCH.  80,  11
  • (2019)  Synthesis of arbutin–gold nanoparticle complexes and their enhanced performance for whitening.  ARCHIVES OF PHARMACAL RESEARCH.  42,  11
  • (2019)  Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.  ELIFE.  8, 
  • (2019)  Protective Effects of Nargenicin A1 against Tacrolimus-Induced Oxidative Stress in Hirame Natural Embryo Cells.  INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH.  16,  6

단행본

  • (2021)  생명과학자의 서재.  담앤북스.  공동
  • (2021)  암의 분자생물학.  (주)도서출판 월드사이언스.  공동

특허/프로그램

  • 마이크로 RNA를 유효성분으로 함유하는 Ninj1 억제용 시약조성물(Reagent composition for inhibiting Ninj1 comprising microRNA).  10-2095-2980000.  20200325.  대한민국
  • 신규한 이소나이트라민 화합물 및 이를 포함하는 대사성 질환 예방 또는 치료용 조성물(Novel Isonitramine Compound and Composition for Preventing or Treating Metabolic Disease Comprising the Same).  16161094.  20200121.  미국
  • 알파-휴물렌(alpha-Humulene)을 유효성분으로 포함하는 소화기계 점막 관련 질환 예방 또는 치료용 조성물(Composition Comprising alpha-Humulene for Preventing or Treating Diseases Associated with Mucous Membrane of Digestive System).  10-2043-8930000.  20191106.  대한민국
  • 알파-휴물렌을 유효성분으로 함유하는 안구 건조증 예방 또는 치료용 조성물(Compositions for Preventing or Treating Dry Eye Syndrome Comprising Alpha-humulene).  10-2040-8100000.  20191030.  대한민국
  • 홍합패각 및 올리고당을 유효성분으로 함유하는 칼슘복합제 및 이의 용도(Calcium complex comprising mussel shell and oligosaccharide and uses thereof).  10-2040-8090000.  20191030.  대한민국
  • 신규한 이소나이트라민 화합물 및 이를 포함하는 대사성 질환 예방 또는 치료용 조성물(Novel Isonitramine Compound and Composition for Preventing or Treating Metabolic Disease Comprising the Same).  10-1799-7930000.  20171115.  대한민국